Metformin Impurities

Metformin is an oral antihyperglycemic agent widely prescribed for the management of type 2 diabetes mellitus, functioning primarily by reducing hepatic glucose production and improving insulin sensitivity. Unlike insulin secretagogues, Metformin does not stimulate insulin release and thus carries a low risk of hypoglycemia. Ensuring the pharmaceutical purity of Metformin is essential to maintain its therapeutic effectiveness, minimize adverse effects, and meet regulatory standards. Impurity profiling plays a crucial role in detecting and controlling degradation products and synthesis-related by-products. Here are some of its known impurities listed below.

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