Chlorothiazide is a thiazide diuretic medication widely used in the management of hypertension and edema associated with conditions like congestive heart failure and renal disorders. It acts by inhibiting sodium reabsorption in the distal tubules of the kidneys, promoting increased excretion of sodium and water. Maintaining the pharmaceutical purity of Chlorothiazide is essential to ensure its therapeutic effectiveness, minimize adverse effects, and meet regulatory standards. Impurity profiling is crucial in detecting and controlling unwanted substances that may arise during manufacturing, storage, or degradation. Here are some of its known impurities listed below.
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