Hydrochlorothiazide is a thiazide diuretic commonly used to treat hypertension and edema associated with conditions such as heart failure, liver disease, and kidney disorders. It works by inhibiting sodium reabsorption in the distal tubules of the kidneys, promoting the excretion of sodium and water, thereby reducing blood volume and pressure. Maintaining the pharmaceutical purity of Hydrochlorothiazide is essential for ensuring its therapeutic effectiveness, patient safety, and compliance with regulatory standards. Impurity profiling plays a crucial role in identifying and controlling unwanted by-products that may arise during manufacturing, storage, or degradation. Here are some of its known impurities listed below.
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