Ibuprofen is a widely used nonsteroidal anti-inflammatory drug (NSAID) indicated for the relief of pain, inflammation, and fever, commonly found under brand names like Advil and Motrin. It functions by inhibiting cyclooxygenase (COX) enzymes, thereby reducing the synthesis of prostaglandins responsible for pain and inflammation. Maintaining the pharmaceutical purity of Ibuprofen is essential to ensure its therapeutic effectiveness, patient safety, and adherence to regulatory standards. Impurity profiling is crucial to detect and control unwanted by-products that may form during its synthesis, storage, or degradation. Here are some of its known impurities listed below.
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